|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
While rs1801131A/C genetic polymorphism is associated with the clinical response, rs1801133C/T and rs2274976A/G genetic polymorphisms are associated with MTX-related AEs in the treatment of RA.
|
20863444 |
2010 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied the associations between the serum uric acid concentration and the following: (i) demographic, anthropometric and other variables previously reported to be associated with serum uric acid concentrations; (ii) the presence of metabolic syndrome and the levels of metabolic syndrome components; and (iii) selected genetic variants of the MTHFR (c.665C>T, c.1286A>C), SLC2A9 (c.844G>A, c.881G>A) and ABCG2 genes (c.421C>A).
|
24827988 |
2014 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls.
|
18513846 |
2008 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) with breast cancer risk and their interaction with alcohol consumption in a case-control study--the Western New York Exposures and Breast Cancer study.
|
19706843 |
2009 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and MTR (rs1805087) with breast cancer risk and their interaction with alcohol consumption in a case-control study--the Western New York Exposures and Breast Cancer study.
|
19706843 |
2009 |
|
Cognition Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that ADHD related cognitive deficit could be attributed to abnormalities in the folate cycle and explored functional single nucleotide polymorphisms in methylenetetrahydrofolate dehydrogenase (rs2236225), reduced folate carrier (rs1051266), and methylenetetrahydrofolate reductase (rs1801131 and rs1801133) in families with ADHD probands (N = 185) and ethnically matched controls (N = 216) recruited following the DSM-IV.
|
25079255 |
2014 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that ADHD related cognitive deficit could be attributed to abnormalities in the folate cycle and explored functional single nucleotide polymorphisms in methylenetetrahydrofolate dehydrogenase (rs2236225), reduced folate carrier (rs1051266), and methylenetetrahydrofolate reductase (rs1801131 and rs1801133) in families with ADHD probands (N = 185) and ethnically matched controls (N = 216) recruited following the DSM-IV.
|
25079255 |
2014 |
|
Attention deficit hyperactivity disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We hypothesized that ADHD related cognitive deficit could be attributed to abnormalities in the folate cycle and explored functional single nucleotide polymorphisms in methylenetetrahydrofolate dehydrogenase (rs2236225), reduced folate carrier (rs1051266), and methylenetetrahydrofolate reductase (rs1801131 and rs1801133) in families with ADHD probands (N = 185) and ethnically matched controls (N = 216) recruited following the DSM-IV.
|
25079255 |
2014 |
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery.
|
28044213 |
2017 |
|
Meniere Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the C677T and A1298C (rs1801133 and rs1801131) polymorphisms in the MTHFR gene and compared them between 1946 adults (986 men and 960 women) participating in the National Institute for Longevity Sciences Longitudinal Study of Aging and 86 cases of MD.
|
23484733 |
2013 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute of Diabetes and Digestive and Kidney Diseases African-American Study of Kidney Disease and Hypertension (AASK) Trial to determine whether decline in glomerular filtration rate (GFR) over ∼4.2 years was predicted by common genetic variation within MTHFR at non-synonymous positions C677T (Ala222Val) and A1298C (Glu429Ala) or by MTHFR haplotypes.
|
21613384 |
2012 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute of Diabetes and Digestive and Kidney Diseases African-American Study of Kidney Disease and Hypertension (AASK) Trial to determine whether decline in glomerular filtration rate (GFR) over ∼4.2 years was predicted by common genetic variation within MTHFR at non-synonymous positions C677T (Ala222Val) and A1298C (Glu429Ala) or by MTHFR haplotypes.
|
21613384 |
2012 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute of Diabetes and Digestive and Kidney Diseases African-American Study of Kidney Disease and Hypertension (AASK) Trial to determine whether decline in glomerular filtration rate (GFR) over ∼4.2 years was predicted by common genetic variation within MTHFR at non-synonymous positions C677T (Ala222Val) and A1298C (Glu429Ala) or by MTHFR haplotypes.
|
21613384 |
2012 |
|
Renal sclerosis with hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute of Diabetes and Digestive and Kidney Diseases African-American Study of Kidney Disease and Hypertension (AASK) Trial to determine whether decline in glomerular filtration rate (GFR) over ∼4.2 years was predicted by common genetic variation within MTHFR at non-synonymous positions C677T (Ala222Val) and A1298C (Glu429Ala) or by MTHFR haplotypes.
|
21613384 |
2012 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63).
|
27996344 |
2017 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP).
|
31815282 |
2019 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed.
|
25075036 |
2014 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed.
|
25075036 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with oral cancer risk, and their joint effects with individual smoking habits on oral cancer risk are discussed.
|
21737671 |
2011 |